1株野鸟源H5N2亚型禽流感病毒对SPF鸭的致病性分析

doi:10.11843/j.issn.0366-6964.2013.09.025

Abstract

Abstract:

This experiment was conducted to study the pathogenicity of the H5N2 avian influenza virus isolates from wild bird and investigate its pathogenic and occurring mechanism. Two-week-old SPF duck (Shaoxing sheldrake) was infected by an isolate of LPAIV H5N2 subtype as natural infection model in this study. The results showed that virus can propagate more effectively in digestive tract. Despite of absent of obvious clinical symptoms, the infected SPF duck shed virus for a longer time. The virus has the infection ability by direct contact. The antibody against HI can be detected at 7-14 days after infection, and the antibody level reached its peak at the third week after infection. Besides, this virus can propagate with higher level only in caecum tonsil and bursa of fabricius, while the tissue damage occurred in bursa of fabricius, lung, thymus and pancreas in varying degrees. The results indicated that duckling plays a key role during AIV spread，whether it (even wild duck) cause by certain differences between the laboratory imitation nature and true nature infection, it remains to be further explored.

CLC Number:

S852.659.5

GUAN Xue-ting, LIU Jing-li, CHAI Hong-liang, CHENG Cheng, ZHANG Yi, ZUO Xin-yue, CHEN Xiao-mei, LIU Yi-nan, HUA Yu-ping, LI Yan-bing. Pathogenicity of SPF Ducks Infected with the Low-pathogenic Avian Influenza Virus H5N2 Subtype Isolated from Wild Birds[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2013, 44(9): 1504-1508.

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Pathogenicity of SPF Ducks Infected with the Low-pathogenic Avian Influenza Virus H5N2 Subtype Isolated from Wild Birds

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